Research

Endothelial activation after coronary artery bypass surgery: comparison between on-pump and off-pump techniques

Vallely MP, Bannon PG, Bayfield MS, Hughes CF, Kritharides L Heart Lung Circ 2010 Aug;19(8):445-52 PMID: 20418159 Abstract BACKGROUND: The effects of off-pump coronary artery bypass (OPCAB) surgery on endothelial cell activation are poorly understood. Endothelial cell adhesion molecules (CAMs) are expressed and released when the endothelium is activated. We compared plasma CAMs (E-selectin, ICAM-1…

Animal models for the assessment of novel vascular conduits

Byrom MJ, Bannon PG, White GH, Ng MK J. Vasc. Surg. 2010 Jul;52(1):176-95 PMID: 20299181 Abstract The development of an ideal small-diameter conduit for use in vascular bypass surgery has yet to be achieved. The ongoing innovation in biomaterial design generates novel conduits that require preclinical assessment in vivo, and a number of animal models…

Three common CARD15 mutations are not responsible for the pathogenesis of Crohn’s disease in Iranians

Teimoori-Toolabi L, Vahedi H, Mollahajian H, Kamali E, Hajizadeh-Sikaroodi S, Zeinali S, Tabrizian T, Olfati G, Rashtak S, Malekzadeh F, Ghoddosi A, Malekzadeh R Hepatogastroenterology 2010 Mar-Apr;57(98):275-82 PMID: 20583427 Abstract BACKGROUND/AIMS: Crohn’s disease frequency has increased in recent years in Iran. Genetic and environmental factors predispose people to this disease. Mutation in Caspase Recruitment Domain…

Transcatheter aortic valve implantation for high-risk patients with severe aortic stenosis: A systematic review

Yan TD, Cao C, Martens-Nielsen J, Padang R, Ng M, Vallely MP, Bannon PG J. Thorac. Cardiovasc. Surg. 2010 Jun;139(6):1519-28 PMID: 19846124 Abstract OBJECTIVES: The present systematic review objectively assessed the safety and clinical effectiveness of transcatheter aortic valve implantation for patients at high surgical risk with severe aortic stenosis. METHODS: Electronic searches were performed…

Survivor treatment selection bias and outcomes research: a case study of surgery in infective endocarditis

Sy RW, Bannon PG, Bayfield MS, Brown C, Kritharides L Circ Cardiovasc Qual Outcomes 2009 Sep;2(5):469-74 PMID: 20031879 Abstract BACKGROUND: Recent studies in infective endocarditis have suggested an association between surgery and reduced mortality. However, these studies did not account for survivor treatment selection bias, which is an underrecognized source of error in observational studies….

Extrapleural pneumonectomy for malignant pleural mesothelioma: outcomes of treatment and prognostic factors

Yan TD, Boyer M, Tin MM, Wong D, Kennedy C, McLean J, Bannon PG, McCaughan BC J. Thorac. Cardiovasc. Surg. 2009 Sep;138(3):619-24 PMID: 19698846 Abstract OBJECTIVE: This study aimed to evaluate the perioperative and long-term outcomes associated with extrapleural pneumonectomy for patients with malignant pleural mesothelioma. METHODS: From October 1994 to April 2008, 70 patients…

Systematic review and meta-analysis of randomized and nonrandomized trials on safety and efficacy of video-assisted thoracic surgery lobectomy for early-stage non-small-cell lung cancer

Yan TD, Black D, Bannon PG, McCaughan BC J. Clin. Oncol. 2009 May;27(15):2553-62 PMID: 19289625 Abstract PURPOSE: The current randomized trials comparing video-assisted thoracic surgery (VATS) lobectomy with open lobectomy for patients with early-stage non-small-cell lung cancer (NSCLC) have been of small size. We performed the present meta-analysis of the randomized and nonrandomized comparative studies…

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