Research Publications
Our primary focus at The Baird Institute is to encourage and fund research to improve the surgical outcomes and quality of life for patients facing heart or lung surgery. The funds we raise go directly to research that improves the surgical procedures associated with heart and lung surgery. Improvements can include less intrusive procedures as well as techniques that improve survival rates.
Below you will find a list of publications that our surgeons and research fellows have been involved in writing.
Optimized murine HFpEF models for translational preclinical studies
Introduction: The most clinically representative murine models of heart failure with preserved ejection fraction (HFpEF) include a ‘2-hit’ model combining nitrosative stress with metabolic perturbation and a ‘3-hit’ model that also includes ageing. Both models have important limitations with regard to substrain and sex. Methods: The 2-hit model protocol was modified to reproduce HFpEF in both C57BL/6N…
Correction: Feasibility and reliability of a smartwatch to detect atrial fibrillation after cardiac surgery: a prospective study
No Abstract Available
Second cross-clamp in less invasive mitral valve repair for degenerative mitral regurgitation: Predictors and outcomes
Objective: To evaluate the incidence, echocardiographic patterns, operative strategies, and results of patients receiving a second cross-clamping in the large population of the Mini Mitral International Registry. Methods: We examined 4577 patients with degenerative mitral regurgitation (MR) who underwent less invasive mitral repair. Patients with nondegenerative disease, planned valve replacement, and surgery without cross-clamping were excluded. Multivariable…
Feasibility and reliability of a smartwatch to detect atrial fibrillation after cardiac surgery: a prospective study
Background: Atrial fibrillation, the world’s predominant cardiac arrhythmia, frequently emerges as a complication post-cardiac surgery, leading to serious outcomes like strokes, heart failures, and even death. Due to its often-silent nature, detecting it can be challenging. Smartwatches present a potential solution, offering screening that is more rigorous. Objective: This prospective observational study sought to assess the Withings…
Evolution of Minimally Invasive Mitral Valve Repair: 30-Year Experience From a High-Volume Center
Background: Minimally invasive mitral valve repair (MVr) is a reproducible, widely adopted, and routinely performed surgical procedure. It is often performed in combination with tricuspid valve (TV) surgery. However, evidence on long-term results and their evolution over time is limited. This study evaluated whether outcomes of isolated minimally invasive MVr or minimally invasive MVr with concomitant…
Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding: The CLIP-II Randomized Noninferiority Clinical Trial
Importance: Liquid-stored platelets have a shelf-life of 5 to 7 days, limiting availability and resulting in wastage. Objective: To assess the effectiveness and safety of dimethyl sulfoxide-cryopreserved platelets, which have a shelf-life of 2 years, as a treatment for cardiac surgery bleeding. Design, setting, and participants: The Cryopreserved vs Liquid Platelets II (CLIP-II) trial was a multicenter, randomized,…
Mitral valve surgery in mitral annular calcification
Mitral annular calcification (MAC) remains a challenging pathology in the context of mitral valve disease. It is associated with known cardiovascular risk factors, as well as a variety of chronic inflammatory, infective, or connective tissue diseases. Surgically, patients are at specific operative risk for atrioventricular dehiscence or rupture and/or injury to the circumflex artery. To…
Epigenetic Reprogramming via TET2 Prevents Medial Calcification and Restores Vascular Smooth Muscle Cell Identity.
Vascular calcification arises from the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and is a hallmark of many cardiovascular pathologies. This study identifies Tet2, a DNA demethylase, as a critical epigenetic regulator that prevents this phenotypic switch. VSMC-specific loss of Tet2 promotes osteogenic differentiation, apoptosis, increased infiltration of Trem2hi macrophages and medial aortic calcification. High-dose…
