Research Publications
Our primary focus at The Baird Institute is to encourage and fund research to improve the surgical outcomes and quality of life for patients facing heart or lung surgery. The funds we raise go directly to research that improves the surgical procedures associated with heart and lung surgery. Improvements can include less intrusive procedures as well as techniques that improve survival rates.
Below you will find a list of publications that our surgeons and research fellows have been involved in writing.
Role of Concomitant Coronary Artery Bypass Grafting in Valve Surgery for Infective Endocarditis
Background: It is current practice to perform concomitant coronary artery bypass grafting (CABG) in patients with infective endocarditis (IE) who have relevant coronary artery disease (CAD). However, CABG may add complexity to the operation. We aimed to investigate the impact of concomitant CABG on perioperative outcomes in patients undergoing surgery for IE. Methods: We retrospectively used data…
Is the pulmonary pressure directly correlated with the operative risk in patients with isolated tricuspid valve surgery?
Background: Severe pulmonary hypertension is a relative contraindication for isolated tricuspid valve (TV) surgery. However, some patients may still benefit from TV surgery. We hypothesized that pulmonary pressure alone is an inadequate predictor of outcomes post-TV surgery, and that aorto-pulmonary pressure quotient (AoP/PAP) is a better predictor. Methods: From 2005 to 2019, a total of 122 patients…
Resection of a Tumor With Thymic-like Differentiation and Reconstruction of the Innominate Artery
Carcinomas showing thymic-like differentiation (CASTLE tumors) are very rare entities requiring an individualized therapeutic plan. This report describes a case of reconstruction of the innominate artery after radical resection of the tumor in a patient in whom a custom-made cerebral shunt was used for continuous cerebral perfusion.
Sutureless versus rapid deployment aortic valve replacement: results from a multicentric registry
Background: To compare clinical and hemodynamic in-hospital outcomes of patients undergoing sutureless versus rapid deployment aortic valve replacement (SURD-AVR) in the large population of the Sutureless and Rapid Deployment International Registry (SURD-IR). Methods: We examined 4695 patients who underwent isolated or combined SURD-AVR. The “sutureless” Perceval valve was used in 3133 patients and the “rapid deployment” Intuity…
Atrial fibrillation management during septal myectomy for hypertrophic cardiomyopathy: A systematic review
Introduction: Atrial fibrillation is common in patients with hypertrophic cardiomyopathy, and significantly impacts mortality and morbidity. In patients with atrial fibrillation undergoing septal myectomy, concomitant surgery for atrial fibrillation may improve outcomes. Methods: A systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All studies reporting the outcomes of combined septal…
Gastrointestinal complications following cardiac surgery
Co-investigators: Dr Nicholas McNamara, Dr John Brookes, Dr Benjamin Robinson, Prof Michael Solomon, Prof Paul Bannon Purpose/Introduction: Gastrointestinal (GI) complications following cardiac surgery have been associated with significant morbidity and mortality. The pathogenesis of GI complications in this cohort is thought to revolve around splanchnic hypoperfusion, whereby the circulatory shifts during cardiac surgery greatly affect…
Optimizing the discovery and assessment of therapeutic targets in heart failure with preserved ejection fraction
There is an urgent need for models that faithfully replicate heart failure with preserved ejection fraction (HFpEF), now recognized as the most common form of heart failure in the world. In vitro approaches have several shortcomings, most notably the immature nature of stem cell-derived human cardiomyocytes [induced pluripotent stem cells (iPSC)] and the relatively short…
Intracardiac Echocardiography for Point-of-Care Guided Left Ventricular Assist Device Implantation: Surgical Implications for COVID-19
Data from animal models is now available to initiate assessment of human safety and feasibility of wide-angle three-dimensional intracardiac echocardiography (3D ICE) to guide point-of-care implantation of percutaneous left ventricular assist devices in critical care settings. Assessment of these combined new technologies could be best achieved within a surgical institution with pre-existing expertise in separate…
