Baird News

RPA – The TV Show

The RPA series on Channel 9 follows patients who bravely and generously share their stories. Filmed at Royal Prince Alfred Hospital in Camperdown, Sydney, this reality program shows the everyday workings of this major hospital, detailing the sicknesses and operation procedures of its patients.

In Episode 2 of the new series, which aired on 3 April 2023, Cardiothoracic Surgeon and Baird Institute board member, A/Professor Christopher Cao had a starring role alongside his patient, Theo. After getting COVID, doctors discovered during a routine scan that father of 3, Theo, had a large lesion (the size of a small fist) in his chest.

Dr Cao explained to Theo that most surgeons would do a full chest opening – a sternotomy – to remove the tumour, but he on the other hand, typically utilises minimally invasive robotic surgery for this procedure – a revolutionary approach. During surgery, Dr Cao makes three small cuts of about 8mm on the side of the chest and inserts ports into the holes. Through the ports, Dr Cao is able to insert a number of instruments that he controls to separate the lesion from the heart and blood vessels and chest wall. This robotic surgery means that Theo will be in hospital for just 2 or 3 days, on painkillers for 2 to 3 weeks and he can go back to his physical activities in a much shorter period of time than if the lesion had been removed via a full chest opening. Luckily, all turned out well for Theo. See this episode, and all others in the series, on 9Now.

James Wadland Night of Hearts 2023

The 9th Annual JWNOH was held at Sharkies at Kareela on 2nd April, 2023. The event is held in honour of my late husband, James Wadland, who at 35yrs of age passed away from an aortic aneurysm in 2013. Each year on his birthday, the event raises funds for The Baird Institute to support the continuation of their ground-breaking research into heart and lung disease. It is an opportunity for family and friends to come together and remember our beloved James and his legacy.

As a family we were suddenly left without a husband and father and our world became unbearable and devastating. Discovering the cause of his death was shocking knowing that his bicuspid valve was genetic and that it could have been prevented. Working with The Baird Institute has given me an insight into the importance of research in heart disease and genetics. A not-for-profit organization that relies purely on donations from its supporters is remarkable.

The Baird Institute has given me the opportunity to channel my grief into raising awareness of the work they do and to support research that continues to save lives so that other families don’t go through the trauma of losing a loved one. As a mum of two children knowing that even though we have been forever affected by such a devastating loss, we can choose to make a difference!

Please join our JWNOH team in this year’s City2Surf on 13th August 2023 and let’s make a difference together!

Building a Platform for Surgical Performance and Audit

Dhairya Vayada, BBiomedSc,
Data Research Assistant, The Baird Institute

With a substantial amount of information collected before, during and after a surgery, there is a large amount of data generated. This data can be used to uncover rich insights into the surgical process, helping the surgeons to identify trends, performance, and ways to improve patient outcomes and experience.

One of the challenges is to present the data in a way that enables the surgeons to interpret insights and draw meaningful information from it. I am currently working on a secure clinical data analytics platform to present anonymized data in a graphical and interactive format. Key components of this platform include; surgical dashboards which enable each surgeon to analyse their key metrics and performance as well as observe the unit’s performance as a whole; a resource utilization dashboard to observe how the unit uses resources during surgery; and finally the plotting of surgical patients’ locations on an interactive map.

The platform has enabled the automation of some parts of the auditing process, allowing graphs and tables for the quarterly surgical audit to be generated instantly. The platform is also modular and future-oriented so technologies such as artificial intelligence and machine learning can be rapidly implemented, helping the cardiothoracic surgeons identify areas for potential research and scope for patient outcome improvement.

The Sydney Heart Bank (SHB)

Centre for Heart Failure & Diseases of the Aorta

Centre for Heart Failure and Diseases of the Aorta
A/Prof Sean Lal

In 1989, in collaboration with the late Dr. Victor Chang AO, Prof. Cris dos Remedios established the Sydney Heart Bank (SHB) at the University of Sydney to collect and store explanted human hearts for research purposes. The SHB now comprises over 18,000 human cardiac samples from explanted failing hearts and non-diseased donor hearts from patients at St Vincent’s Hospital Sydney. In more recent years, under the Directorship of A/Prof Sean Lal, the SHB is now a biobank of international standards that has also expanded to prospectively procure heart, aortic, and vascular samples from patients at Royal Prince Alfred Hospital in collaboration with Prof Paul Bannon and Dr Jacky Loa.

The SHB is completely not-for-profit and collaborates with over 30 research laboratories within Australia and around the world. The independent external research projects are in conjunction with our own in-house projects. The research projects range from examining cardiac regeneration, contractile mechanics cellular and molecular cardiology, cardiac proteomics, vascular diseases, and aortic diseases.

We gratefully thank the support of The Baird Institute and the Faculty of Medicine and Health at the University of Sydney in maintaining the infrastructure, staffing, and operations of the SHB. We also acknowledge the patients and staff of St. Vincent’s Hospital Sydney and Royal Prince Alfred Hospital.

The Sydney Heart BankSHB Executive

  • A/Prof Sean Lal
  • Prof Paul Bannon

Biobank Manager

  • Dr Cassandra Malecki

Biobank RA

  • Ms Sheena Mali

RPA biobank team

  • Prof Paul Bannon (Cardiothoracic Surgeon)
  • Dr Jacky Loa (Vascular Surgeon)
  • A/Prof Sean Lal (Cardiologist)
  • Senior clinical nurses; Lisa Turner & Lorna Beattie,

The Role of the Anterior Mitral Leaflet on Left Ventricuclar Function

Dr Laurencie Brunel & Prof. Paul Bannon

The left side of the heart has 2 chambers (left atrium and ventricle) separated by a valve called the mitral valve. The mitral valve prevents back flow and supports the function of the left ventricle (main pumping chamber of the heart that supplies oxygenated blood to the body and thus essential for life). This valve has two leaflets (anterior and posterior) hinged on the annulus (an ill-defined structure at the junction between the atrium and ventricle).

When the original mitral valve fails to work properly, it can be replaced with an artificial one with the aim of restoring effective blood supply to the body.  Valves can be replaced either by opening the chest and heart to insert it (open technique), or by inserting the valve using a minimally invasive approach via a large blood vessel (transcatheter insertion).  When the original valve is replaced with an artificial one, there are the options of removing the original one or leaving it in place alongside the new one, or even altering the shape of the original valve.  However, all options can severely impair left ventricular function and thus the effective pumping of oxygenated blood to the entire body.  Ineffective pumping of blood is a major reason for mortality following valve replacement.

The objectives of our research were to establish a stable and reproducible model to evaluate the effects of commonly used surgical options for the original valve when inserting an artificial valve in clinical practice, with the aim of ultimately improving left ventricular function and therefore quality of life and survival rates of patients requiring a mitral valve replacement.

In current clinical practice, the anterior mitral leaflet is most commonly removed at the time of a valve insertion. Our first study aimed to investigate methods of safely retaining the original anterior leaflet at the time of insertion.  This first study found that retaining that leaflet in place, when replacing the valve, caused obstruction in blood flow inside the heart, so clearly, we had to develop other techniques to avoid this.

Some minimally invasive valve replacements are designed to deal with the anterior mitral leaflet, as are some open surgical techniques.  So, during our second study we looked at the effects of these techniques on heart function. These studies demonstrated that these methods also adversely affected the heart.  Clinically, this at least in part explains the poor outcomes in patients who already have poor heart function going into surgery and in fact we may be making it worse.

We did further investigation into other techniques and the results were all the same. This led us to the conclusion that future designs of any valves, needed to understand that the entire mitral valve apparatus had to be retained, but in some way, we needed to fix the valve function.  Hence the importance of this study.

A Bequest: Reverend Jack and Mrs Winsome Sharp

Winsome Sharp passed away in 2022 at the grand old age of 98.  She would have been 100 years of age this month.  Winsome and her husband Jack were avid and longstanding supporters of The Baird Institute, having made their first donation back in 2010.  Jack was the one with heart issues and unfortunately, he passed away from a heart attack in 2014, but Winsome continued their annual donations until her death in 2022. In addition to their annual support, the Sharps left a Gift in their Will of $20,000 to The Baird Institute and this was passed on to us in March this year.

Reverend Jack and Mrs Winsome Sharp were missionaries with Methodist Overseas Missions in Papua New Guinea for 32 years. They travelled to their first posting, at Namatanai on New Ireland, a few weeks after their marriage in 1950. They had several more postings in Papua New Guinea, with the last one being in Bougainville.  In 1968 the United Church in Papua New Guinea and the Solomon Islands was inaugurated and Reverend Sharp was elected as the first Moderator, presiding over the whole church.

They returned to Australia in 1982 and moved to Windsor, New South Wales, for Jack’s last appointment at the Windsor Uniting Church before he retired in 1988. However, even in retirement they together remained active and committed members of the community, volunteering with Lifeline and local community organisations in addition to the church. Jack and Winsome were people of great faith, working very closely together in dedicated service to people and ministry.

The Baird Institute is extremely grateful for the Sharp’s generosity in supporting heart and lung surgical research and we pass on our condolences to their families.

If you are interested in finding out more information about leaving a Gift in your Will to The Baird Institute or for a confidential discussion, call our CEO, Catherine Rush on 02/9550 2350

Carol’s Story

Simon Fieldhouse Painting

Art in Surgery – A patient’s story

In late September 2018, at the age of 75, I underwent a triple heart bypass operation performed by Professor Paul Bannon at Royal Prince Alfred Hospital, having been referred to him by my cardiologist, Dr Sean Lal.

The operation was very successful and the care I received at RPAH was outstanding. I am sure that this care helped in my good recovery.  Prior to the surgery, I consented to participate in the ‘Art in Surgery’ program whereby an artist – Simon Fieldhouse – came into the operating theatre and did a painting of me undergoing heart surgery.  The painting is adjacent.

I have 3 sons, Simon, Andrew and Paul.  The artist was Simon, the ICU Doctor was Andrew and the Surgeon was Paul!! – maybe a good omen!

I am mindfully indebted to the wonderful expertise of the medical and nursing staff for my now good health and extended life and as such I decided to support The Baird Institute with a monthly donation so that the knowledge and expertise that results from The Baird Institute’s research will continue to grow and help to save even more lives.

I congratulate Professor Bannon on being named top researcher in his field earlier this year and thank him and Dr. Sean Lal from my heart, for my heart, which has enabled me to continue to enjoy a healthy lifestyle.

The Baird Institute’s 21st Birthday

The Baird Institute 21st Birthday Celebration

On 17th November, 2022 we celebrated our 21st birthday at Rydges Hotel in Camperdown. It was a great night spent with our team and our many supporters, to mark 21 years of ground-breaking cardiothoracic surgical research.  Although we usually get together annually with our supporters to provide an update on our work, this had not been possible for the past 3 years due to Covid-19. Our last event was held in December 2019 just as the first cases of Covid were evidenced overseas.

Our Patron, The Hon Michael Kirby AC CMG commenced the proceedings with a welcome to the Institute’s supporters that were present and described how much their support was appreciated over the past 21 years.   Our Chair, Professor Paul Bannon followed with an explanation of the pivotal role The Baird Institute had played in cardiothoracic surgical research and training since our inception.  In addition, he explained how The Baird Institute had developed from a typical surgical research group in 2001 focusing on surgical outcomes to undertaking translational research today.

Board member, Associate Professor Sean Lal, talked about the newly established Centre for Heart Failure & Diseases of The Aorta and its focus on three major areas; innovative heart valve design, heart failure and the biomechanics of the human aorta.

Prof. Bannon introduced Dr Robert Hume, our post-doctoral fellow who will lead a team in the Centre for Heart Failure & Diseases of The Aorta. This team will utilise human and model system heart failure so as to understand key disease processes in heart failure and aortic disease.

Prof Bannon led a Q&A with two of his patients – twin brothers Paul & Simon Molino – who both had open heart surgery in 2022, a few weeks apart from each other. They were just 39 years of age. They generously shared with the group their experience pre and post-surgery and the benefit that our research could have on their families. It was very moving hearing of their experience – both quite different – in addition to the impact on them and their families

Finally, generous Baird Institute supporter, Will Bird talked briefly on behalf of his family about their decision to support The Baird Institute’s Aortic Research program. The Bird family are greatly assisting us in the funding of Dr Hume’s fellowship over the next 3 years and for this we are most grateful.  Will’s father, Rob Bird, died of an Aortic Dissection in 2010 and his family have made a commitment to funding aortic disease research at The Baird Institute.  As a result, we have named the aortic research program after Rob Bird.  Prof Bannon presented Will and his family with a plaque in recognition of their support for The Baird Institute over several years.

Following the presentations, we were served with some excellent canapes and refreshments.  Everybody sang Happy Birthday to The Baird Institute and cut a very large cake in memory of its 21 years.  We are very appreciative to Rydges Hotel and Mr Jack Tolani for their generosity in funding a large part of the birthday celebrations.

Photos from the big event:

Clinical Trials Update

Heart Studies, Research & Clinical Trials

Lorna Beattie, Lisa Turner and Carmel Oostveen, the Clinical Trial co-coordinators, coordinate all Cardiovascular Clinical Trials within Royal Prince Alfred Hospital (RPAH) assisted by Dhairya Vayada who is a research assistance employed by the Baird Institute who assists with research and data management within the department.

There continues to be challenges following the pandemic, but we are happy to say that the recruitment for clinical trials and biobanks at RPAH are on the rise.

RPAH ran the TRiCS III trial back in 2015-2016 which assessed transfusion strategies in patients having heart surgery. This trial showed that a restrictive blood transfusion strategy is as effective as a liberal strategy. However, it was also noted that restrictive transfusion practices may put younger patients at risk of harm and TRiCS IV will now be assessing blood transfusion strategies in a younger patient population. The research team hope to commence TRiCS IV at RPAH in December.

The team are also working on an application to CHeReL (Centre for Health Record Linkage) for a mass data linkage project looking at long-term outcomes in cardiac surgery for 12,000 patients which will have a significant impact in the cardiovascular space. There are several students, registrars and Cardiothoracic Trainee’s involved in the process of collating and analysing data.

The Cardiac Precision Group and The Aortic Research Group

Dr Cassandra Malecki

BMedSc (Hons), PhD

Since starting in my postdoctoral position, I have assisted with the progression of multiple projects within the cardiac precision group and the aortic group, overseen the collection of tissue and management of the Sydney Heart Bank and initiated my own research project and research questions.

Coming from a background in molecular biology, I was first able to assist in helping students in executing techniques in the lab to examine the level of expression of relevant genes in heart failure samples and how these levels compare to those in healthy hearts. I have also been involved in helping prepare samples for large-scale analysis of human aortic and cardiac samples, which have allowed for the investigation over 4500 proteins and genome-wide RNA expression in different types of heart failure and aortic disease, contributing to the findings of multiple projects, with some currently being written up for publication.

I was given the chance to the take the lead on an exciting project investigating the changes that occur in the heart as we age. Age is one of the biggest risk factors of heart failure, and therefore understanding the changes that occur in the heart as we age will assist in the development of preventative and therapeutic options for heart failure. We are currently looking at levels of proteins, metabolites, and lipids and the expression of thousands of genes in hearts of individuals over the age of 50 and comparing these to hearts of individuals 20 and younger. This is the first ever study to characterise the molecular changes that occur in normal ageing of the human heart.  We have found very interesting and novel results including changes in levels of contractile proteins and seen how the heart changes its ability to utilise energy as we age. We are currently writing up the results of this study, with the aim to submit it for publication before the end of 2022, to a highly prestigious scientific journal.

Most of this research is made possible due to the utilisation of the unique resource that is the Sydney Heart Bank. A major part of my role has involved collecting precious human heart and aortic tissue samples from RPAH, processing the tissue, managing the Sydney Heart Bank database, and preparing samples for other members of the lab and collaborators around the world who are using the tissue for their own research projects. I have also optimised protocols for tissue collection and processing and have put systems in place to keep thorough track of samples coming in and out of the heart bank and tracking sample information.

To expand on the cardiac ageing project mentioned earlier, I have taken a particular interest in developing a project that examines how the aorta changes at a molecular level with age, and how these changes may impact the heart. The aorta naturally becomes stiff as we age. The stiffer the aorta is, the harder the heart must work to pump blood into the aorta and around the body.  If the heart is under these higher stresses for an extended period, this can lead to heart disease. Therefore, understanding the relationship between the aorta and heart in ageing may bring to light new therapeutic options for heart disease. After thoroughly examining the Sydney Heart bank database, I identified healthy heart tissue and healthy aorta that were from the same individual, with samples covering a wide age range.  I have used these samples to examine the molecular relationship between the aorta and the heart as we age. Currently, genome-wide RNA expression and protein levels of the tissue samples have been completed, with the data to be analysed in the next few months and future experiments in the planning process.

Stay in the loop

Subscribe to our Heart to Heart newsletter to keep up with the latest developments in heart and lung research from The Baird Institute.

Ms. Jivani Murugan

BSocSc

Jivani is a Policy Officer employed at the Aboriginal Health and Medical Research Council of NSW. She is a Criminal Justice graduate from Macquarie University and is passionate about reducing health inequities for all communities. Jivani was born with a congenital heart condition and has had three open heart surgeries since her first at 10 days old. Her most recent, at age 23, introduced her to The Baird Institute and Professor Bannon.

Jivani campaigned for our 2021 Mid-year Appeal to fundraise and spread awareness of cardiothoracic surgery. She is an advocate for heart health and uses her position as a patient to raise awareness in the community and continues to showcase how surgery has saved her life. Jivani has enrolled in a Master of Public Health at Macquarie University commencing in 2023.

Mr. Ross Saunders

Ross is a business leader based in Sydney and originating from the United Kingdom. He currently runs the Australia & New Zealand operation for a global manufacturer with specialisation in business transformation, governance & compliance, program management, and strategic planning.

With particular interest in organisational transformation, Ross has led business and digital transformation programs across several global and national organisations including RS Group plc, Wesfarmers Industrial & Safety and Essentra plc.

Notably, Ross is also a post-operative recipient of valve-sparing aortic root replacement surgery, provided by Prof. Bannon and his team at Royal Prince Alfred Hospital, Sydney.

Associate Professor Christopher Cao

BSc (Med), MBBS (1st Hon), PhD, FRACS

Associate Professor Christopher Cao is a Consultant Cardiothoracic Surgeon at Royal Prince Alfred Hospital, Concord Hospital, Chris O’Brien Lifehouse, Macquarie University Hospital, and Sydney Adventist Hospital.

Christopher graduated with First Class Honours from the University of New South Wales and scored 99/99 in both steps of the United States Medical Licensing Exam. This was followed by a pre-internship at Yale University, USA. After his cardiothoracic surgical training with the Royal Australasian College of Surgeons in Sydney, his specialist Fellowship training was completed at the Memorial Sloan Kettering Cancer Center in New York, USA, the world’s oldest and largest private cancer center. He was then invited to be a Faculty Member in the Department of Cardiothoracic Surgery at New York University Medical Center, where he gained additional experience in minimally invasive cardiac surgery as well as heart and lung transplantation.

Associate Professor Cao has authored or co-authored more than 100 articles in high-impact international scientific journals and textbooks. His PhD with Sydney University was focused on the surgical management of pleural and lung cancers. He is the first author in one of the largest international registries on robotic surgery to date. His clinical interests include minimally invasive and robotic thoracic and cardiac surgery.

Dr Sean Lal

BMedSci(Hons), MBBS(Hons), MPhil(Med), PhD(Med), FRACP

Dr Sean Lal is an Academic in the Faculty of Medicine and Health at the University of Sydney and a Consultant Cardiologist at Royal Prince Alfred Hospital, sub-specialising in heart failure and cardiac MRI. He is also the Chair of the Heart Failure Council for the Cardiac Society of Australia and New Zealand.

Sean completed his undergraduate degree in Medical Science with first class honours at the University of Sydney, receiving full academic scholarship. He pursued his graduate Medical Degree (MBBS) and a Master of Medicine by research (MPhil) at the University of Sydney, where he was awarded the Dean’s Scholarship, the Medical Foundation Scholarship and the University of Sydney Bercovici Medal. As a medical doctor, Sean completed all of his general and specialty clinical training at Royal Prince Alfred Hospital. During his cardiology training, he was awarded a National Churchill Fellowship to study mechanisms of cardiac regeneration at Harvard Medical School.

Sean has a clinical and research interest in heart failure. For his PhD in this field, he was awarded a combined National Health and Medical Research Council (NHMRC) and National Heart Foundation (NHF) Scholarship, as well as the NHMRC and Royal Australasian College of Physicians (RACP) scholarship for research excellence.

He was also awarded a Commonwealth Endeavour Postgraduate Fellowship to Harvard University and Massachusetts Institute of Technology (MIT), where he undertook proof of concept studies demonstrating the intrinsic regenerative capacity of the human heart following myocardial infarction; whilst also gaining clinical experience in acute heart failure management in the cardiac ICU at the Brigham and Women’s Hospital.

Sean is the Director of the Sydney Heart Bank at the University of Sydney, which is one of the largest biorepositories of cryopreserved human heart tissue in the world. He is the Head of the Cardiac Research Laboratory in the School of Medical Sciences at the Charles Perkins Centre, which focuses on basic science and translational research into human heart failure.

Dr Brian Plunkett

Dr Brian Plunkett is an Australian-trained Cardiothoracic Surgeon with a special interest in transcatheter valve procedures and minimally invasive cardiac surgery.

Following the completion of his Royal Australasian College of Surgeons training, he undertook a Mitral Valve Repair fellowship in Edmonton, Canada, followed by dual Harvard Fellowships in Advanced Cardiac Surgery and Transcatheter Structural Heart Procedures.

He was awarded the inaugural Michael Davidson Structural Heart Fellowship by the American Thoracic Surgery Foundation, making him one of only a handful of surgeons formally trained in Transcatheter Structural Heart procedures.

He is the surgical lead of the Royal Prince Alfred Hospital transcatheter valve program, supervisor of cardiothoracic surgical training, and surgical director of the ECMO program. Dr. Plunkett’s areas of specialisation include all transcatheter valve procedures (MitraClip, TriClip, TAVI, TMVI, paravalvular leak closure), aortic valve replacement, mitral and tricuspid valve repair, all-arterial coronary bypass surgery, atrial fibrillation surgery, and pacemaker, cardiac defibrillator and resynchronisation device implantation.

He has been involved in several first-in-man procedures since his return from the USA, and is a champion of novel technologies to improve patient safety in cardiac procedures at Sydney Adventist Hospital.

Dr Benjamin Robinson

Mr Benjamin Robinson is an adult cardiothoracic surgeon with a long association with The Baird Institute. Whilst a medical student, he completed honours research with the Baird on outcomes in early-stage non-small cell lung cancer, under the supervision of Professor Brian McCaughan. He was awarded a Baird Institute Fellowship for this work. He subsequently trained in cardiothoracic surgery at Royal Prince Alfred Hospital and was the inaugural Baird Institute – Stanford University exchange scholar. Mr Robinson later completed a cardiac surgery clinical fellowship at Bart’s Heart Centre in London. He then worked as a consultant cardiothoracic surgeon at St. James’s Hospital in Dublin, before returning to Sydney to take up appointments at Royal Prince Alfred, Concord Repatriation General and Strathfield Private Hospitals.

Mr Robinson has experience in the spectrum of adult cardiac surgery, including coronary, valvular and aortic disease, as well as in general thoracic surgery. He has specific clinical interest in minimal access aortic valve surgery, arterial coronary grafting and aortic surgery. He has completed postgraduate study at Cambridge University and has academic interests in surgical outcomes research and epidemiology.

Professor Tristan Yan

Dr Tristan Yan is the Head of Department of Thoracic Surgery at Chris O’Brien Lifehouse. Professor Yan graduated from the University of New South Wales (UNSW) with Bachelor of Science (Medicine), Bachelor of Medicine and Bachelor of Surgery. He also completed three postgraduate higher degrees, Master of Surgery (USyd), Doctor of Medicine (UNSW) and Doctor of Philosophy (UNSW). He was trained at Royal Prince Alfred Hospital and St Vincent’s Hospital in Sydney and then obtained Cardiothoracic Surgery Fellowship from the Royal Australasian College of Surgeons. Following advanced specialty fellowships in the United States, England, Scotland and Germany, he specializes in minimally invasive cardiovascular surgery, and minimally invasive thoracic surgery.

Professor Tristan Yan is dedicated to surgical innovations. He applies the latest pioneering techniques to minimize surgical trauma and access sites and thus achieves a more rapid and comfortable recovery for his patients. He first completed his general surgical fellowship with Paul Sugarbaker in the United States, one of the most prominent surgeons in the world. He was then closely trained by the pioneer of Minimally Invasive Thoracic Surgery, Mr. William Walker, in Edinburgh, where he mastered the technical expertise of video-assisted thoracoscopic surgery (VATS) to perform complex lung resections, such as lobectomy and segmentectomy.

Associate Professor Chris Cao

After completing his medical degree at the University of New South Wales with First Class Honours, Christopher attended his pre-internship at Yale University, USA. He scored 99/99 for his United States Medical Licensing Exam, and completed his Cardiothoracic surgical training in Sydney. Concurrently, Christopher completed his PhD degree with Sydney University, focusing on the surgical management of lung and pleural diseases.

After completing his surgical training with the Royal Australasian College of Surgeons, Christopher was invited to a Fellowship at the Memorial Sloan Kettering Cancer Centre in New York City, one of the largest cancer centres in the world. This was followed by a Fellowship in New York University, where he was asked to join the Faculty in the Department of Cardiothoracic Surgery. His fellowship was focused on robotic and minimally invasive thoracic surgery, treating lung cancers, mediastinal tumours, mesothelioma, and other lung-related diseases. During his 18-month Fellowship at MSKCC and NYU, Christopher was fortunate to work with some of the leading international surgeons, gaining invaluable clinical and academic experience.

With over 100 publications in international peer-reviewed journal articles and book chapters, A/Prof Cao has a keen interest in thoracic surgery, particularly the treatment of lung cancers through minimally invasive surgery. He has made more than 50 presentations in international meetings as a Faculty Member in Paris, New York, Edinburgh, Taipei, Sydney, and Guangzhou. Christopher has personally supervised students and residents from Sydney University, University of New South Wales, Cornell University and New York University.

He is a member of the Australian and New Zealand Society of Cardiac and Thoracic Surgery, and works as a Consultant Surgeon at Lifehouse, Royal Prince Alfred Hospital, Concord Hospital, Sydney Adventist Hospital, and Macquarie University Hospital.

Dr Mike Byrom

Dr Michael Byrom is a modern, innovative cardiothoracic surgeon with training and experience in New Zealand, Australia, the United Kingdom, and Italy. Particular areas of expertise include:

  • Truly minimally-invasive surgery to the aortic valve that avoids complete division of the breast bone (hemi-sternotomy, right anterior mini-thoracotomy); allowing faster recovery and return to normal activities
  • Mitral valve repair with excellent repair rates and outcomes – resulting from diverse training in France, Italy, and the United Kingdom
  • Avoidance of the need for anticoagulation through valve selection, valve repair, and surgical treatment of atrial fibrillation
  • Minimally-invasive lung resection, avoiding a large thoracotomy wound and enabling faster recovery and return to normal activities with reduced pain and discomfort
  • Sternal and rib titanium plate fixation of chronic non-united fractures
  • Performing these procedures while minimising risk of complications, allowing Dr Byrom to achieve world-class results for his patients

Dr Matthew Bayfield

Dr Matthew Bayfield is an extremely experienced cardiothoracic surgeon with a broad range of skills and special interests within his field. He has performed more than 6000 heart and lung procedures. Dr Bayfield has hospital appointments at Strathfield Private Hospital, Royal Prince Alfred Hospital and Concord Hospital. His surgical interests include:

  • Coronary artery surgery: Dr Bayfield is one of Australia’s busiest coronary surgeons; with particular focus on minimal access incisions, and use of in-situ bilateral internal mammary artery grafts for enhanced longevity of the benefit of coronary revascularization.
  • Aortic root and arch surgery: Dr Bayfield has been performing aortic root and arch surgery since 1995, when he completed a Cardiovascular Fellowship at the University of Virginia in the USA. His focus is on o minimal access incisions, short cardiopulmonary bypass times, and for arch surgery antegrade cerebral perfusion with cerebral oxygen saturation monitoring.
  • Surgery for emphysema / CAL: Dr Bayfield was trained in open lung reduction surgery whilst doing a fellowship at the University of Virginia in 1995. Since that time he has developed thoracoscopic techniques for the procedure, and since 2003 been an implanter of endobronchial valves as a minimally invasive alternative to surgery. With over 100 endobronchial valve case experience, and long term follow-up of these patients, he is one of Australia’s most experienced endobronchial valve proceduralist.
  • Correction of pectus defects: Dr Bayfield has a special interest in correction of both pectus and carinatum defects, with techniques including implantation of Nuss bar under video-assisted control, and open radical sternochondroplasty.Lung cancer surgery: Dr Bayfield has been in surgical partnershio with Professor Brian McCaughan since 1996, and was trained by him as a registrar. Prof McCaughan is Australia’s most experienced and prolific lung cancer surgeon, has published widely on many aspects of its treatment, and has been awarded Medal of the Order of Australia (AM) for services to health in respect to his work on malignant mesothelioma.
  • Pacemaker and defibrillator implantation: Dr Bayfield was trained in device implantation as a young surgeon in the 1980’s and has developed skills to ensure that a device can be safely and reliably implanted even in the most difficult case with minimal risk. He was trained in cardiac resynchronzation therapy techniques at the introduction of that technology. He has regular pacemaker and defibrillator implantation lists at Royal Prince Alfred Hospital, Strathfield Private Hospital, and Concord Hospital.
  • Surgical treatment for ischaemic cardiomyopathy: Dr Bayfield trained in heart and lung transplantation whilst at the University of Virginia. With this skill base he has been able to develop a multi-faceted approach to treat patients whose hearts have been damaged by coronary artery disease (heart attack). These therapies include coronary artery bypass, mitral valve repair, and implantation of CRT defibrillators.

Professor Paul Bannon

Professor Paul Bannon is an adult cardiothoracic surgeon of international standing with clinical appointments at Royal Prince Alfred Hospital, Concord and Strathfield Private Hospital. At Royal Prince Alfred Hospital Professor Bannon is the Head of Department of Cardiothoracic Surgery, Co-Chair of the Institute for Academic Surgery, Director of the Robotic Training Institute and the current President of the Medical Officers Association. At the University of Sydney, he holds the inaugural Professorial Chair of Cardiothoracic Surgery and the Bosch Chair of Surgery. He is also the current Head of the Discipline of Surgery for the Sydney Medical School and the Academic Director of the newly opened Translational Research Facility or Hybrid Theatre at the Charles Perkins Centre. He is the Chair of The Baird Institute for Applied Heart and Lung Surgical Research. Professionally he is the Past President of the Australian and New Zealand Society of Cardiothoracic Surgeons (ANZSCTS) and in that role serves on the steering Committee for the ANZSCTS National Cardiac Surgical Database, the National TAVI Accreditation Committee and is the Cardiac Surgical Chair of the Medical Benefits Schedule review program. For the Ministry of Health NSW he has been in the role of Co-Chair of the Cardiac Devices Committee for the Agency of Clinical Innovation.

Professor Bannon graduated from the University of Sydney in 1987, completed a PhD from the same institution in 1998 and was awarded a FRACS (CTh) in 1998. He has a particular passion for translational research in the areas of congenital aortic and mitral valve disease, biomaterials and biocompatibility, limitation of blood product usage in cardiac surgery, the inflammatory response to bypass and the development of academic surgical careers. He has authored or co-authored more than 120 scientific papers, published in peer-reviewed journals. He is co-editor-in-chief of the Annals of Cardiothoracic Surgery, a Medline listed multimedia journal of cardiothoracic surgery. Professor Bannon has a reputation as the ‘surgeons surgeon’ and has particular expertise in surgery of the aortic root and arch, high-risk re-do surgery, total-arterial coronary artery bypass grafting and surgery for hypertrophic cardiomyopathy.

Professor Richmond W. Jeremy

MB BS PHD FRACP FAHA FESC FCSANZ GAICD

Professor Richmond Jeremy’s medical and cardiology training were at the University of Sydney and Royal Prince Alfred Hospital.

His clinical research career includes a PhD on coronary physiology and a post doctoral research Fellowship at Johns Hopkins Hospital, Baltimore before returning to the University of Sydney and Royal Prince Alfred Hospital.

University of Sydney responsibilities have included service as Associate Dean Sydney, Medical School, Head of Central Clinical School and Pro Vice-Chancellor, Campus Infrastructure and Services.

Professional responsibilities have included service as Editor-in-Chief of Heart Lung and Circulation, membership of Boards on National Heart Foundation (NSW), Royal Australasian College of Physicians (Adult Medicine Division) and Cardiac Society of Australia and New Zealand.

Mr. Shaun Clyne

MA LLM (Syd)

Shaun is a corporate lawyer based in Sydney. He is the Australian Head of the Mergers & Acquisitions practice. He regularly advises on a wide range of corporate and securities law issues for public listed companies including takeovers, schemes of arrangement and capital raisings. He advises on Australian Stock Exchange compliance matters and regularly acts for both bidders and targets in connection with takeover bids and schemes of arrangement (hostile and friendly) for ASX-listed companies.

A leading practitioner in equity capital markets, Shaun has also advised numerous companies on their initial public offerings and capital raisings (rights issues, AREO’s, placements, employee share and options plans).

Shaun has presented at a variety of seminars and conferences and published several papers in his areas of specialisation.

His areas of expertise are mergers and acquisitions, corporate advisory and capital markets.

Ms. Joanne Wade

BEc LLB

Joanne Wade has been a plaintiff lawyer since her admission to the Supreme Court of NSW in 1996 and has worked in asbestos litigation for well over 18 years. Joanne is an Accredited Specialist in Personal Injury Law and prides herself on her communication with her clients and, on many occasions, her clients’ families. She understands the importance and need to handle all her cases with the utmost diligence and compassion. Joanne has acted for hundreds of people suffering from mesothelioma, lung cancer, asbestosis and asbestos related pleural disease. Her clients are everyday people who have worked hard all their lives and deserve justice. Joanne acted for Steven Dunning in his claim against BHP Billiton Limited in the Dust Diseases Tribunal of NSW (Dunning vBHP Billiton Limited [2014] NSWDDT 3). Mr Dunning suffered from malignant pleural mesothelioma and in a landmark decision; the court awarded Mr Dunning the highest amount for damages for pain and suffering in NSW. Joanne went on to represent Mr Dunning in the Appeal before the NSW Court ofAppeal where BHP’s appeal was unanimously dismissed (BHPBilliton Limited v Dunning [2015] NSWCA 55). Joanne has also successfully acted for the late Bevan McGrath in his claim against Allianz Australia Insurance Limited, for his condition of asbestos related pleural disease and ensured that case was resolved on a provisional damages basis. Mr McGrath went on to develop mesothelioma, one of only a small number of cases where he then brought a second claim for further damages because his first claim was resolved on a provisional basis. Joanne successfully acted for Mr McGrath in both his claims and the late Mr McGrath successfully received further damages in a judgment by the court (McGrath v Allianz AustraliaInsurance Limited [2011] NSWDDT). The judgement was upheld on appeal (Allianz Australia Insurance Limited v McGrath [2011]NSWCA 153).

“It is with great privilege to work with people suffering from asbestos illnesses, and the greatest satisfaction formed is securing a result for those people to help ease their suffering, and to know their families will be looked after.”Joanne takes great pride in the work Slater and Gordon have undertaken in representing victims of asbestos disease, unions and asbestos support groups, including the work of Ken Fowlie in 2004 who acted for the ACTU and asbestos support groups in negotiations with James Hardie to secure an agreement which will ensure current and future victims of asbestos –related diseases would be fully compensated for years to come.Joanne is a passionate advocate and one thing that separatesJoanne from other lawyers is perspective, with her own father being exposed to asbestos working at Cockatoo IslandDockyard, she is in the unique position of seeing it from both angles.“My clients are generally people who have worked hard all their lives, and are lovely people who deserve justice. I am glad to fight for that justice and to make a difference to their lives.”

Expertise

  • Asbestos Claims
  • Dust Disease Board Appeals
  • Dust Diseases Claims
  • Compensation Claims

Career History

  • Slater and Gordon since 2008 (practice group leader)
  • 2000-2007 Watkins Tapsell (partner)
  • 1996-2000 Watkins Tapsell (lawyer)
  • 1992-1995 NSW Crown Solicitors Office (paralegal clerk)

Professor Clifford F. Hughes

AO MBBS FRACS FACC FACS FCSANZ

Professor Cliff Hughes is President of the International Society for Quality in Health Care. Until March 2015 he was the Chief Executive Officer of the Clinical Excellence Commission, a statutory health corporation established in 2004 to build capacity and design programs to promote and support improvement in quality and safety for health services across NSW. He has been chairman or member of numerous Australian state and federal committees associated with quality, safety and research in clinical practice for health care services. He has held various positions in the Royal Australasian College of Surgeons, including Senior Examiner in Cardiothoracic Surgery and member of the College Council. In November 2015 the College bestowed upon him the highest award given to a Fellow in his lifetime, the Sir Hugh Devine Medal. He has received awards for his national and international work including an Alumni Award from the University of NSW. He has led five medical teams to China and has performed cardiac surgery in Hong Kong, Singapore, Malaysia, India and Bangladesh. In 1998, he was made an Officer in the Order of Australia (AO) in recognition of his contributions and “service to cardiac surgery, international relationships and the community”. In June 2014, the University of NSW conferred upon him the degree of Doctor of Science, its peak academic award.

Professor Jeffrey Braithwaite

BA, MIR (Hons), MBA, DipLR, PhD, FIML, FCHSM, FFPHRCP (UK), FAcSS (UK), Hon FRACMA, FAHMS

Professor Jeffrey Braithwaite, BA, MIR (Hons), MBA, DipLR, PhD, FIML, FCHSM, FFPHRCP (UK), FAcSS (UK), Hon FRACMA, FAHMS is Founding Director, Australian Institute of Health Innovation, Director, Centre for Healthcare Resilience and Implementation Science, and Professor of Health Systems Research, Faculty of Medicine and Health Sciences, Macquarie University. His research examines the changing nature of health systems, attracting funding of more than AUD$131 million (EUR€81.8 million, GBP£70.8 million).

He has contributed over 470 peer-reviewed publications presented at international and national conferences on more than 915 occasions, including 97 keynote addresses. His research appears in journals such as JAMA, British Medical Journal, The Lancet, BMC Medicine, BMJ Quality & Safety, and International Journal for Quality in Health Care. He has received numerous national and international awards for his teaching and research.

He is interested in the Anthropocene and the impact of human activity on human and species’ health, population and climate. He blogs at http://www.jeffreybraithwaite.com/new-blog/.

Further details are available at his Wikipedia entry: http://en.wikipedia.org/wiki/Jeffrey_Braithwaite.

Ms. Michelle Sloane

BA MA MBA CMAHRI MAPsS​

Michelle’s background is in psychology and human resources working for many years in senior executive positions at Westpac, IBM and Unilever. Twenty years ago she established a human resources management consulting practice, Diversity Management, and led that organisation for 16 years. Michelle has worked extensively in the areas of change management, organisational analysis and design, human resource management, program management, stakeholder engagement as well as leadership development and training.

Michelle has a Master of Business Administration from the University of Technology, a Master of Arts (Psychology) from the University of Sydney and a Bachelor of Arts from the University of New South Wales. In addition Michelle is a Graduate of the Institute of Company Directors (GAICD).

Michelle has also been a Councillor for the City of Willoughby in Sydney. During her time as Councillor and Deputy Mayor, she has worked tirelessly with the local community advocating across a range of local and state-wide issues. Her interest in local government was developed over many years as a very active volunteer in her local community.

Professor Paul G. Bannon

MBBS PhD FRACS

Professor Paul Bannon is the Chair of The Baird Institute for Applied Heart and Lung Surgical Research, a not-for-profit medical research institute established in 2001, to improve the outcomes and better the lives of those undergoing heart and lung surgery.

He is Head of Department, Cardiothoracic Surgery at Royal Prince Alfred Hospital, Sydney and holds the Chair of Cardiothoracic Surgery and the Bosch Chair of Surgery, University of Sydney. He has performed over 2500 adult cardiac surgical procedures ranging from coronary artery bypass to complex aortic root and arch reconstructions. He is President of the Australia and New Zealand Society of Cardiac and Thoracic Surgeons and is the Society representative to the Cardiac Surgery National Database. He is the Co-Chair of the Institute of Academic Surgery at RPAH where he also oversees the robotic surgical program. He heads the National MBS Taskforce Review for Cardiac Surgery and has held various positions in the Royal Australasian College of Surgeons and Royal Prince Alfred Hospital.

Professor Bannon’s teaching responsibilities are currently to all years of the Graduate Medical Program at Sydney Medical School, University of Sydney. He supervises local and international Doctorate, Masters and Honours students as well as international elective students. He is the Co Editor-in-Chief of The Annals of Cardiothoracic Surgery and a Director of the CORE Group for International Collaborative Research. Professor Bannon has published widely in books, journals and conference proceedings on cardiothoracic surgery, basic science and evidence based medicine.

He has a particular passion for translational research in the areas of congenital aortic and mitral valve disease, hypertrophic cardiomyopathy, biomaterials and biocompatibility, limitation of blood product usage in cardiac surgery, the inflammatory response to bypass and the development of academic surgical careers. He is a current Chief Investigator on NHMRC and NHF grants for biomaterials and congenital heart disease research as well as a current NHMRC CRE grant on mechanical circulatory support. His role in the CRE is to produce NHMRC Clinical Practice Guidelines and measure their dissemination, adoption and outcomes. He personally oversees more than $500,000 worth of research funding annually. His Department currently runs 16 clinical trials amongst many other laboratory and clinically based projects.