Baird News

James Wadland Night of Hearts 2023

The 9th Annual JWNOH was held at Sharkies at Kareela on 2nd April, 2023. The event is held in honour of my late husband, James Wadland, who at 35yrs of age passed away from an aortic aneurysm in 2013. Each year on his birthday, the event raises funds for The Baird Institute to support the continuation of their ground-breaking research into heart and lung disease. It is an opportunity for family and friends to come together and remember our beloved James and his legacy.

As a family we were suddenly left without a husband and father and our world became unbearable and devastating. Discovering the cause of his death was shocking knowing that his bicuspid valve was genetic and that it could have been prevented. Working with The Baird Institute has given me an insight into the importance of research in heart disease and genetics. A not-for-profit organization that relies purely on donations from its supporters is remarkable.

The Baird Institute has given me the opportunity to channel my grief into raising awareness of the work they do and to support research that continues to save lives so that other families don’t go through the trauma of losing a loved one. As a mum of two children knowing that even though we have been forever affected by such a devastating loss, we can choose to make a difference!

Please join our JWNOH team in this year’s City2Surf on 13th August 2023 and let’s make a difference together!

Building a Platform for Surgical Performance and Audit

Dhairya Vayada, BBiomedSc,
Data Research Assistant, The Baird Institute

With a substantial amount of information collected before, during and after a surgery, there is a large amount of data generated. This data can be used to uncover rich insights into the surgical process, helping the surgeons to identify trends, performance, and ways to improve patient outcomes and experience.

One of the challenges is to present the data in a way that enables the surgeons to interpret insights and draw meaningful information from it. I am currently working on a secure clinical data analytics platform to present anonymized data in a graphical and interactive format. Key components of this platform include; surgical dashboards which enable each surgeon to analyse their key metrics and performance as well as observe the unit’s performance as a whole; a resource utilization dashboard to observe how the unit uses resources during surgery; and finally the plotting of surgical patients’ locations on an interactive map.

The platform has enabled the automation of some parts of the auditing process, allowing graphs and tables for the quarterly surgical audit to be generated instantly. The platform is also modular and future-oriented so technologies such as artificial intelligence and machine learning can be rapidly implemented, helping the cardiothoracic surgeons identify areas for potential research and scope for patient outcome improvement.

The Sydney Heart Bank (SHB)

Centre for Heart Failure & Diseases of the Aorta

Centre for Heart Failure and Diseases of the Aorta
A/Prof Sean Lal

In 1989, in collaboration with the late Dr. Victor Chang AO, Prof. Cris dos Remedios established the Sydney Heart Bank (SHB) at the University of Sydney to collect and store explanted human hearts for research purposes. The SHB now comprises over 18,000 human cardiac samples from explanted failing hearts and non-diseased donor hearts from patients at St Vincent’s Hospital Sydney. In more recent years, under the Directorship of A/Prof Sean Lal, the SHB is now a biobank of international standards that has also expanded to prospectively procure heart, aortic, and vascular samples from patients at Royal Prince Alfred Hospital in collaboration with Prof Paul Bannon and Dr Jacky Loa.

The SHB is completely not-for-profit and collaborates with over 30 research laboratories within Australia and around the world. The independent external research projects are in conjunction with our own in-house projects. The research projects range from examining cardiac regeneration, contractile mechanics cellular and molecular cardiology, cardiac proteomics, vascular diseases, and aortic diseases.

We gratefully thank the support of The Baird Institute and the Faculty of Medicine and Health at the University of Sydney in maintaining the infrastructure, staffing, and operations of the SHB. We also acknowledge the patients and staff of St. Vincent’s Hospital Sydney and Royal Prince Alfred Hospital.

The Sydney Heart BankSHB Executive

  • A/Prof Sean Lal
  • Prof Paul Bannon

Biobank Manager

  • Dr Cassandra Malecki

Biobank RA

  • Ms Sheena Mali

RPA biobank team

  • Prof Paul Bannon (Cardiothoracic Surgeon)
  • Dr Jacky Loa (Vascular Surgeon)
  • A/Prof Sean Lal (Cardiologist)
  • Senior clinical nurses; Lisa Turner & Lorna Beattie,

The Role of the Anterior Mitral Leaflet on Left Ventricuclar Function

Dr Laurencie Brunel & Prof. Paul Bannon

The left side of the heart has 2 chambers (left atrium and ventricle) separated by a valve called the mitral valve. The mitral valve prevents back flow and supports the function of the left ventricle (main pumping chamber of the heart that supplies oxygenated blood to the body and thus essential for life). This valve has two leaflets (anterior and posterior) hinged on the annulus (an ill-defined structure at the junction between the atrium and ventricle).

When the original mitral valve fails to work properly, it can be replaced with an artificial one with the aim of restoring effective blood supply to the body.  Valves can be replaced either by opening the chest and heart to insert it (open technique), or by inserting the valve using a minimally invasive approach via a large blood vessel (transcatheter insertion).  When the original valve is replaced with an artificial one, there are the options of removing the original one or leaving it in place alongside the new one, or even altering the shape of the original valve.  However, all options can severely impair left ventricular function and thus the effective pumping of oxygenated blood to the entire body.  Ineffective pumping of blood is a major reason for mortality following valve replacement.

The objectives of our research were to establish a stable and reproducible model to evaluate the effects of commonly used surgical options for the original valve when inserting an artificial valve in clinical practice, with the aim of ultimately improving left ventricular function and therefore quality of life and survival rates of patients requiring a mitral valve replacement.

In current clinical practice, the anterior mitral leaflet is most commonly removed at the time of a valve insertion. Our first study aimed to investigate methods of safely retaining the original anterior leaflet at the time of insertion.  This first study found that retaining that leaflet in place, when replacing the valve, caused obstruction in blood flow inside the heart, so clearly, we had to develop other techniques to avoid this.

Some minimally invasive valve replacements are designed to deal with the anterior mitral leaflet, as are some open surgical techniques.  So, during our second study we looked at the effects of these techniques on heart function. These studies demonstrated that these methods also adversely affected the heart.  Clinically, this at least in part explains the poor outcomes in patients who already have poor heart function going into surgery and in fact we may be making it worse.

We did further investigation into other techniques and the results were all the same. This led us to the conclusion that future designs of any valves, needed to understand that the entire mitral valve apparatus had to be retained, but in some way, we needed to fix the valve function.  Hence the importance of this study.

A Bequest: Reverend Jack and Mrs Winsome Sharp

Winsome Sharp passed away in 2022 at the grand old age of 98.  She would have been 100 years of age this month.  Winsome and her husband Jack were avid and longstanding supporters of The Baird Institute, having made their first donation back in 2010.  Jack was the one with heart issues and unfortunately, he passed away from a heart attack in 2014, but Winsome continued their annual donations until her death in 2022. In addition to their annual support, the Sharps left a Gift in their Will of $20,000 to The Baird Institute and this was passed on to us in March this year.

Reverend Jack and Mrs Winsome Sharp were missionaries with Methodist Overseas Missions in Papua New Guinea for 32 years. They travelled to their first posting, at Namatanai on New Ireland, a few weeks after their marriage in 1950. They had several more postings in Papua New Guinea, with the last one being in Bougainville.  In 1968 the United Church in Papua New Guinea and the Solomon Islands was inaugurated and Reverend Sharp was elected as the first Moderator, presiding over the whole church.

They returned to Australia in 1982 and moved to Windsor, New South Wales, for Jack’s last appointment at the Windsor Uniting Church before he retired in 1988. However, even in retirement they together remained active and committed members of the community, volunteering with Lifeline and local community organisations in addition to the church. Jack and Winsome were people of great faith, working very closely together in dedicated service to people and ministry.

The Baird Institute is extremely grateful for the Sharp’s generosity in supporting heart and lung surgical research and we pass on our condolences to their families.

If you are interested in finding out more information about leaving a Gift in your Will to The Baird Institute or for a confidential discussion, call our CEO, Catherine Rush on 02/9550 2350

Carol’s Story

Simon Fieldhouse Painting

Art in Surgery – A patient’s story

In late September 2018, at the age of 75, I underwent a triple heart bypass operation performed by Professor Paul Bannon at Royal Prince Alfred Hospital, having been referred to him by my cardiologist, Dr Sean Lal.

The operation was very successful and the care I received at RPAH was outstanding. I am sure that this care helped in my good recovery.  Prior to the surgery, I consented to participate in the ‘Art in Surgery’ program whereby an artist – Simon Fieldhouse – came into the operating theatre and did a painting of me undergoing heart surgery.  The painting is adjacent.

I have 3 sons, Simon, Andrew and Paul.  The artist was Simon, the ICU Doctor was Andrew and the Surgeon was Paul!! – maybe a good omen!

I am mindfully indebted to the wonderful expertise of the medical and nursing staff for my now good health and extended life and as such I decided to support The Baird Institute with a monthly donation so that the knowledge and expertise that results from The Baird Institute’s research will continue to grow and help to save even more lives.

I congratulate Professor Bannon on being named top researcher in his field earlier this year and thank him and Dr. Sean Lal from my heart, for my heart, which has enabled me to continue to enjoy a healthy lifestyle.

The Baird Institute’s 21st Birthday

The Baird Institute 21st Birthday Celebration

On 17th November, 2022 we celebrated our 21st birthday at Rydges Hotel in Camperdown. It was a great night spent with our team and our many supporters, to mark 21 years of ground-breaking cardiothoracic surgical research.  Although we usually get together annually with our supporters to provide an update on our work, this had not been possible for the past 3 years due to Covid-19. Our last event was held in December 2019 just as the first cases of Covid were evidenced overseas.

Our Patron, The Hon Michael Kirby AC CMG commenced the proceedings with a welcome to the Institute’s supporters that were present and described how much their support was appreciated over the past 21 years.   Our Chair, Professor Paul Bannon followed with an explanation of the pivotal role The Baird Institute had played in cardiothoracic surgical research and training since our inception.  In addition, he explained how The Baird Institute had developed from a typical surgical research group in 2001 focusing on surgical outcomes to undertaking translational research today.

Board member, Associate Professor Sean Lal, talked about the newly established Centre for Heart Failure & Diseases of The Aorta and its focus on three major areas; innovative heart valve design, heart failure and the biomechanics of the human aorta.

Prof. Bannon introduced Dr Robert Hume, our post-doctoral fellow who will lead a team in the Centre for Heart Failure & Diseases of The Aorta. This team will utilise human and model system heart failure so as to understand key disease processes in heart failure and aortic disease.

Prof Bannon led a Q&A with two of his patients – twin brothers Paul & Simon Molino – who both had open heart surgery in 2022, a few weeks apart from each other. They were just 39 years of age. They generously shared with the group their experience pre and post-surgery and the benefit that our research could have on their families. It was very moving hearing of their experience – both quite different – in addition to the impact on them and their families

Finally, generous Baird Institute supporter, Will Bird talked briefly on behalf of his family about their decision to support The Baird Institute’s Aortic Research program. The Bird family are greatly assisting us in the funding of Dr Hume’s fellowship over the next 3 years and for this we are most grateful.  Will’s father, Rob Bird, died of an Aortic Dissection in 2010 and his family have made a commitment to funding aortic disease research at The Baird Institute.  As a result, we have named the aortic research program after Rob Bird.  Prof Bannon presented Will and his family with a plaque in recognition of their support for The Baird Institute over several years.

Following the presentations, we were served with some excellent canapes and refreshments.  Everybody sang Happy Birthday to The Baird Institute and cut a very large cake in memory of its 21 years.  We are very appreciative to Rydges Hotel and Mr Jack Tolani for their generosity in funding a large part of the birthday celebrations.

Photos from the big event:

Clinical Trials Update

Heart Studies, Research & Clinical Trials

Lorna Beattie, Lisa Turner and Carmel Oostveen, the Clinical Trial co-coordinators, coordinate all Cardiovascular Clinical Trials within Royal Prince Alfred Hospital (RPAH) assisted by Dhairya Vayada who is a research assistance employed by the Baird Institute who assists with research and data management within the department.

There continues to be challenges following the pandemic, but we are happy to say that the recruitment for clinical trials and biobanks at RPAH are on the rise.

RPAH ran the TRiCS III trial back in 2015-2016 which assessed transfusion strategies in patients having heart surgery. This trial showed that a restrictive blood transfusion strategy is as effective as a liberal strategy. However, it was also noted that restrictive transfusion practices may put younger patients at risk of harm and TRiCS IV will now be assessing blood transfusion strategies in a younger patient population. The research team hope to commence TRiCS IV at RPAH in December.

The team are also working on an application to CHeReL (Centre for Health Record Linkage) for a mass data linkage project looking at long-term outcomes in cardiac surgery for 12,000 patients which will have a significant impact in the cardiovascular space. There are several students, registrars and Cardiothoracic Trainee’s involved in the process of collating and analysing data.

The Cardiac Precision Group and The Aortic Research Group

Dr Cassandra Malecki

BMedSc (Hons), PhD

Since starting in my postdoctoral position, I have assisted with the progression of multiple projects within the cardiac precision group and the aortic group, overseen the collection of tissue and management of the Sydney Heart Bank and initiated my own research project and research questions.

Coming from a background in molecular biology, I was first able to assist in helping students in executing techniques in the lab to examine the level of expression of relevant genes in heart failure samples and how these levels compare to those in healthy hearts. I have also been involved in helping prepare samples for large-scale analysis of human aortic and cardiac samples, which have allowed for the investigation over 4500 proteins and genome-wide RNA expression in different types of heart failure and aortic disease, contributing to the findings of multiple projects, with some currently being written up for publication.

I was given the chance to the take the lead on an exciting project investigating the changes that occur in the heart as we age. Age is one of the biggest risk factors of heart failure, and therefore understanding the changes that occur in the heart as we age will assist in the development of preventative and therapeutic options for heart failure. We are currently looking at levels of proteins, metabolites, and lipids and the expression of thousands of genes in hearts of individuals over the age of 50 and comparing these to hearts of individuals 20 and younger. This is the first ever study to characterise the molecular changes that occur in normal ageing of the human heart.  We have found very interesting and novel results including changes in levels of contractile proteins and seen how the heart changes its ability to utilise energy as we age. We are currently writing up the results of this study, with the aim to submit it for publication before the end of 2022, to a highly prestigious scientific journal.

Most of this research is made possible due to the utilisation of the unique resource that is the Sydney Heart Bank. A major part of my role has involved collecting precious human heart and aortic tissue samples from RPAH, processing the tissue, managing the Sydney Heart Bank database, and preparing samples for other members of the lab and collaborators around the world who are using the tissue for their own research projects. I have also optimised protocols for tissue collection and processing and have put systems in place to keep thorough track of samples coming in and out of the heart bank and tracking sample information.

To expand on the cardiac ageing project mentioned earlier, I have taken a particular interest in developing a project that examines how the aorta changes at a molecular level with age, and how these changes may impact the heart. The aorta naturally becomes stiff as we age. The stiffer the aorta is, the harder the heart must work to pump blood into the aorta and around the body.  If the heart is under these higher stresses for an extended period, this can lead to heart disease. Therefore, understanding the relationship between the aorta and heart in ageing may bring to light new therapeutic options for heart disease. After thoroughly examining the Sydney Heart bank database, I identified healthy heart tissue and healthy aorta that were from the same individual, with samples covering a wide age range.  I have used these samples to examine the molecular relationship between the aorta and the heart as we age. Currently, genome-wide RNA expression and protein levels of the tissue samples have been completed, with the data to be analysed in the next few months and future experiments in the planning process.

Medicine With Heart

Louise Baird

Dr Louise Baird’s love of being in a hospital started as a young child when she would go with her father, Cardiac Surgeon, Professor Douglas Baird, to Royal Prince Alfred Hospital on Sundays. While he visited his patients pre-operatively, she would sit in the nurses’ office. These treasured childhood memories were to shape her life. She knew that her parents had met over a patient at the old Camperdown Children’s Hospital, where her mother worked as a paediatric nurse. When she later saw Doug’s Medicine graduation photo, she recognised her grandfather in the background. Doug’s former Physiology Professor was father of his future wife. It was from Louise’s grandfather that Doug had learned all his research skills during his BSc Med Honours year at Sydney University. It was as if featuring by chance in the photo was heralding future connections.

Louise Baird’s love of music started at a similar age. She remembers that when she was 5, she wanted to play the piano like her older sister. Luckily for Louise, a piano teacher lived behind them. From their backyard, she could hear students during their piano lessons, and longed to be playing the same pieces. She soon was. Louise’s musical aspirations grew when she heard a neighbour two doors down, playing the violin. Louise picked up the violin at the age of 8 and hasn’t stopped since. She has fond memories of playing in her school orchestra and in the Sydney Youth Orchestra.

When Louise was a 1st year medical student at UNSW, she heard of the Australian Doctors Orchestra playing in Sydney in 1997 in aid of the Glaucoma Foundation. She was thrilled to hear that the orchestra was not just for doctors, and that medical students were also welcome. She remembers being nervous coming in to her first rehearsal, choosing to sit at the back of the section of second violinists, not knowing anybody. She needn’t have worried. The GP she shared her desk with became a lifelong friend.  That was the welcome beginning of Louise balancing her life in both medicine and music. In 2004 I founded the NSW Doctors Orchestra. Louise heard about it the following year on returning from working overseas and has played in most of our concerts since. Over the years, Louise picked up trinkets of valued advice from her fellow musicians, not just about medicine and training, but also about motherhood, about life. She welcomes orchestra gatherings as an opportunity to touch base with her mentors.

“It is so lovely to come together again” she says. “Each year this is the time just for me.”

Louise cannot imagine life without the Doctors Orchestra. She values these opportunities which have helped her keep up her music despite a busy life with work and family commitments.

“As soon as I know the repertoire for the next concert, I download the music onto my phone and listen to it driving to work and during my exercise walks. That way, even if I can’t fit practice in that day, I’m at least becoming more familiar with the music.”

She feels the benefit of using a different part of her brain.

“Music calms me down. It is my escape. I feel as if my brain has been on a holiday. We strongly believe that taking care of our creative health helps us in our work and contributes to our general wellbeing.”

During the pandemic, many of our members confessed to regretfully neglecting their instruments. This is equivalent to an athlete stopping training. We can’t expect to keep up skills and techniques without practice. Not having a ‘marathon’ concert to train for stopped medical musicians in their tracks.

The orchestra thoroughly enjoyed reconnecting in preparation for the “Harp to Heart” concert staged in the Verbrugghen Hall in the University of Sydney’s Conservatorium of Music on Sunday 25 September. The concert was opened with a fun piece called “Roar” composed by Tasmanian Maria Grenfell. Virtuosic soloist Alice Giles played Boieldieu’s harp concerto to an enthusiastic audience. The second half featured Tchaikovsky’s Symphony no. 6 in B minor, the passionate Pathetique. The word ‘symphony’ means being together in sound, and that was certainly the magic the medical musicians welcomed after a harrowing few years of relative isolation.This year’s concert had special significance for Louise, as the funds raised were donated to The Baird Institute, established in honour of her father Professor Douglas Baird. It was also an opportunity to raise public awareness of The Baird Institute, being Australia’s only dedicated cardiothoracic surgical training and research institute, committed to directly impact the quality of life for patients after surgery and save lives that may otherwise have been lost. Louise talks lovingly of her father and his legacy. He was a pioneer in cardiothoracic surgery in Sydney, trained the current leaders and was a mentor to all who followed in the field. His untimely death from cholangiocarcinoma, just 6 weeks after his diagnosis, at the early age of 55, would have been a devastating loss to his family, friends, patients and colleagues. Louise was just 16 when she lost her father. She remembers him as a leader who picked up on people’s strengths and focused on them. Dr Louise Baird is certainly following her father’s legacy in her care of patients and mentoring of students.

Harp to Heart logoMusicus Medicus aims to improve the health and wellbeing of Australians by using the universal language of music to raise money for charities in medicine and the arts.  For more information, go to www.thedoctorsorchestransw.com.au

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