Research

Ryan JB, Hicks M, Cropper JR, Garlick SR, Kesteven SH, Wilson MK, Feneley MP, Macdonald PS Eur J Cardiothorac Surg 2003 Jun;23(6):898-906 PMID: 12829065 Abstract OBJECTIVE: To determine if the initial rate of troponin I release post-reperfusion reflects the effectiveness of myocardial protection during cardiac allograft preservation. METHODS: A porcine model of orthotopic heart transplantation…

Matuszek MA, Aristoteli LP, Bannon PG, Hendel PN, Hughes CF, Jessup W, Dean RT, Kritharides L Atherosclerosis 2003 Jun;168(2):389-96 PMID: 12801624 Abstract BACKGROUND: Molecules which egress from atherosclerotic arteries may function as plasma markers of arterial pathology, but such egress has not been proven with living human coronary arteries. We hypothesised that proteins eluting from…

Barakate MS, Bannon PG, Hughes CF, Horton MD, Callaway A, Hurst T Ann. Thorac. Surg. 2003 May;75(5):1400-5 PMID: 12735553 Abstract BACKGROUND: Emergency coronary artery bypass grafting (CABG) is occasionally necessary for failed percutaneous transluminal coronary angioplasty (PTCA). The aim of this study was to assess the outcome of patients receiving emergency CABG after unsuccessful PTCA…

Ryan JB, Hicks M, Cropper JR, Garlick SR, Kesteven SH, Wilson MK, Feneley MP, Macdonald PS Transplantation 2003 Mar;75(5):625-31 PMID: 12640300 Abstract BACKGROUND: Acute graft dysfunction caused by ischemia-reperfusion injury is recognized as a major source of morbidity and mortality following adult heart transplantation. The aim of this study was to determine whether treating the…

Ryan JB, Hicks M, Cropper JR, Nicholson A, Kesteven SH, Wilson MK, Feneley MP, Macdonald PS J. Heart Lung Transplant. 2003 Mar;22(3):347-56 PMID: 12633703 Abstract BACKGROUND: U74389G (16-desmethyl tirilazad), a 21-aminosteroid or “lazaroid,” inhibits lipid peroxidation, which is an important element of ischemia-reperfusion injury. The aim of this study was to determine whether the addition…

Allman C, Rajaratnam R, Kachwalla H, Hughes CF, Bannon P, Leung DY J Am Soc Echocardiogr 2003 Feb;16(2):188-90 PMID: 12574748 Abstract Hemolytic anemia is a well-known but uncommon complication in patients with prosthetic heart valves. It is most commonly a result of prosthetic valve dysfunction, periprosthetic valvular regurgitation, or both. We report a case of…

Barakate MS, Hemli JM, Hughes CF, Bannon PG, Horton MD Eur J Cardiothorac Surg 2003 Feb;23(2):179-86 PMID: 12559340 Abstract OBJECTIVE: Patients who undergo successful percutaneous transluminal coronary angioplasty (PTCA) may subsequently require operative myocardial revascularization. This review examines whether prior successful PTCA alters outcomes following subsequent coronary artery bypass grafting (CABG). The costs of interventional…

Ryan JB, Hicks M, Cropper JR, Garlick SR, Kesteven SH, Wilson MK, Macdonald PS, Feneley MP Eur J Cardiothorac Surg 2002 Nov;22(5):738-45 PMID: 12414040 Abstract OBJECTIVE: Paradoxically, it has been reported that after 1.5-4 h of hypothermic ischaemic preservation there is complete recovery of contractile function in canine cardiac allografts, as assessed by the preload…

Vallely MP, Bannon PG, Hughes CF, Kritharides L J. Thorac. Cardiovasc. Surg. 2002 Oct;124(4):758-67 PMID: 12324734 Abstract OBJECTIVE: Endothelial cell dysfunction has been implicated in the inflammatory response to cardiopulmonary bypass, and the upregulation of endothelial cell expression of adhesion molecules might promote leukocyte extravasation in vivo. Soluble endothelial cell adhesion molecules are increased after…