Research Publications
Our primary focus at The Baird Institute is to encourage and fund research to improve the surgical outcomes and quality of life for patients facing heart or lung surgery. The funds we raise go directly to research that improves the surgical procedures associated with heart and lung surgery. Improvements can include less intrusive procedures as well as techniques that improve survival rates.
Below you will find a list of publications that our surgeons and research fellows have been involved in writing.
Robotic left transthoracic left main bronchial sleeve resection with preoperative three-dimensional planning
Robotic left main bronchial sleeve resection for endobronchial tumors avoids pneumonectomy while preserving the entire ipsilateral lung parenchyma. Preoperative three-dimensional computed tomography reconstruction guides dissection around the pulmonary artery, pulmonary veins, and left atrium, and Firefly fluorescence imaging enables precise intraoperative tumor localization without needle puncture. We hereby describe a patient with a typical carcinoid…
Mitral Valvular-Ventricular Interactions: Relative Importance and Clinical Implications
An understanding of the numerous ways in which the mitral valve supports left ventricle (LV) function is important to clinicians who evaluate interventions on the mitral valve. Knowledge of the relative contributions to LV function provided by the various support mechanisms allows clinicians to balance the benefits against the adverse effects of mitral interventions. Although…
Targeting RUNX1 protects against diastolic dysfunction in a two-hit mouse model of heart failure with preserved ejection fraction
Aims: Heart failure with preserved ejection fraction (HFpEF) continues to increase in prevalence and has limited treatment options. HFpEF is a systemic condition with a broad phenotype including diastolic dysfunction, pulmonary oedema, exercise intolerance, and left ventricular hypertrophy, collectively resulting in enhanced morbidity and mortality. The transcription factor RUNX1 has recently been identified as a mediator…
Preoperative Intestinal Preconditioning to Prevent Postoperative Vasoplegia After Tricuspid Valve Surgery
Background: Right ventricular dysfunction may lead to intestinal bacterial translocation secondary to portal venous hypertension, thereby contributing to systemic inflammatory response syndrome and vasoplegia after tricuspid valve surgery. This study aimed to evaluate the impact of preoperative intestinal preconditioning (oral antibiotics and laxatives) on the occurrence of postoperative vasoplegia after tricuspid valve surgery. Methods: This retrospective single-center…
Optimized murine HFpEF models for translational preclinical studies
Introduction: The most clinically representative murine models of heart failure with preserved ejection fraction (HFpEF) include a ‘2-hit’ model combining nitrosative stress with metabolic perturbation and a ‘3-hit’ model that also includes ageing. Both models have important limitations with regard to substrain and sex. Methods: The 2-hit model protocol was modified to reproduce HFpEF in both C57BL/6N…
Correction: Feasibility and reliability of a smartwatch to detect atrial fibrillation after cardiac surgery: a prospective study
No Abstract Available
Second cross-clamp in less invasive mitral valve repair for degenerative mitral regurgitation: Predictors and outcomes
Objective: To evaluate the incidence, echocardiographic patterns, operative strategies, and results of patients receiving a second cross-clamping in the large population of the Mini Mitral International Registry. Methods: We examined 4577 patients with degenerative mitral regurgitation (MR) who underwent less invasive mitral repair. Patients with nondegenerative disease, planned valve replacement, and surgery without cross-clamping were excluded. Multivariable…
Feasibility and reliability of a smartwatch to detect atrial fibrillation after cardiac surgery: a prospective study
Background: Atrial fibrillation, the world’s predominant cardiac arrhythmia, frequently emerges as a complication post-cardiac surgery, leading to serious outcomes like strokes, heart failures, and even death. Due to its often-silent nature, detecting it can be challenging. Smartwatches present a potential solution, offering screening that is more rigorous. Objective: This prospective observational study sought to assess the Withings…
