Professor David Kaye is an internationally recognised cardiologist and translational scientist specialising in heart failure and cardiac transplantation. He is Director of Cardiology at The Alfred Hospital and leads the Heart Failure Research Program at the Baker Heart and Diabetes Institute. He is an NHMRC Senior Principal Research Fellow and Adjunct Professor at Monash University.

Professor Kaye’s work spans mechanistic discovery through to first-in-human studies and commercial translation, with a focus on identifying novel therapeutic targets in heart failure. He has made major contributions to understanding the pathophysiology of heart failure, including autonomic dysfunction, myocardial energetics, and more recently HFpEF, where his group has defined key roles for ageing, hypertension, and the gut–cardiac axis.

A hallmark of his career is the translation of biological insights into therapeutic platforms, including development and clinical evaluation of novel pharmacological and device-based strategies for advanced heart failure. This includes leadership of early-phase clinical trials and participation in international multi centre studies, as well as contributions to the development of first-in-class therapies progressing toward commercialisation.

Professor Kaye has authored over 420 peer-reviewed publications in leading journals and has established one of the premier translational heart failure programs in the Asia–Pacific region, integrating human physiology, experimental models, and clinical trials to accelerate therapeutic innovation.