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Research

Application of Clinical Databases to Contemporary Cardiac Surgery Practice: Where are we now?

March 17, 2015

Saxena A, Newcomb AE, Dhurandhar V, Bannon PG Heart Lung Circ 2015 Feb; PMID: 25778623 Abstract Cardiac surgery has embraced and encouraged the use of large, multi-institutional datasets in clinical practice. From a research perspective, database studies have facilitated an increased understanding of cardiac surgery. Among other uses, they have allowed an investigation of disease…

Comparative transcriptome profiling in human bicuspid aortic valve disease using RNA-sequencing

December 30, 2014

Padang R, Bagnall RD, Tsoutsman T, Bannon PG, Semsarian C Physiol. Genomics 2014 Dec;:physiolgenomics.00115.2014 PMID: 25547111 Abstract Intrinsic valvular degeneration and dysfunction is the most common complication of bicuspid aortic valve (BAV) disease. Phenotypically, it ranges from calcific aortic stenosis to redundant or prolapsing regurgitant leaflets. The underlying molecular mechanism underpinning phenotype heterogeneity of valvular…

Replacement of the aortic root with a composite valve-graft conduit: risk factor analysis in 246 consecutive patients

December 3, 2014

Woldendorp K, Starra E, Seco M, Hendel PN, Jeremy RW, Wilson MK, Vallely MP, Bannon PG Heart Lung Circ 2014 Dec;23(12):1187-93 PMID: 25038031 Abstract BACKGROUND: Composite valve-graft (CVG) replacement of the aortic root is a well-studied and recognised treatment for various aortic root conditions, including valvular disease with associated aortopathy. There have been few previous…

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