Research

Outcomes of aortic arch replacement surgery after previous cardiac surgery

Davies RA, Black D, Bannon PG, Bayfield MS, Hendel PN, Hughes CF, Wilson MK, Vallely MP ANZ J Surg 2013 Nov;83(11):827-32 PMID: 23782742 Abstract BACKGROUND: Aortic arch replacement is a potentially high-risk operation and in the re-operative setting has been found to be a risk factor for poor outcome, yet there is a dearth of…

A systematic review and meta-analysis of surgical treatments for malignant pleural mesothelioma

Cao C, Tian D, Park J, Allan J, Pataky KA, Yan TD Lung Cancer 2014 Feb;83(2):240-5 PMID: 24360321 Abstract BACKGROUND: Malignant pleural mesothelioma (MPM) is an aggressive disease of the pleural lining with a dismal prognosis. Surgical treatments of MPM with a curative intent include extrapleural pneumonectomy and extended pleurectomy/decortication (P/D). This meta-analysis aimed to…

ZIC1 is silenced and has tumor suppressor function in malignant pleural mesothelioma

Cheng YY, Kirschner MB, Cheng NC, Gattani S, Klebe S, Edelman JJ, Vallely MP, McCaughan BC, Jin HC, van Zandwijk N, Reid G J Thorac Oncol 2013 Oct;8(10):1317-28 PMID: 24457242 Abstract INTRODUCTION: Epigenetic inactivation of tumor suppressor genes is involved in the development of malignant pleural mesothelioma (MPM). ZIC1, a potential tumor suppressor gene involved…

An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma

Linton A, Cheng YY, Griggs K, Kirschner MB, Gattani S, Srikaran S, Chuan-Hao Kao S, McCaughan BC, Klebe S, van Zandwijk N, Reid G Br. J. Cancer 2014 Jan;110(2):510-9 PMID: 24327015 Abstract BACKGROUND: Malignant pleural mesothelioma (MPM) is an aggressive tumour originating in the thoracic mesothelium. Prognosis remains poor with 9- to 12-month median survival,…

Systematic review of robotic minimally invasive mitral valve surgery

Seco M, Cao C, Modi P, Bannon PG, Wilson MK, Vallely MP, Phan K, Misfeld M, Mohr F, Yan TD Ann Cardiothorac Surg 2013 Nov;2(6):704-16 PMID: 24349971 Abstract BACKGROUND: Robotic telemanipulators have evolved to assist the challenges of minimally invasive mitral valve surgery (MVS). A systematic review was performed to provide a synopsis of the…

Custodiol for myocardial protection and preservation: a systematic review

Edelman JJ, Seco M, Dunne B, Matzelle SJ, Murphy M, Joshi P, Yan TD, Wilson MK, Bannon PG, Vallely MP, Passage J Ann Cardiothorac Surg 2013 Nov;2(6):717-28 PMID: 24349972 Abstract INTRODUCTION: Custodiol cardioplegia is attractive for minimally invasive cardiac surgery, as a single dose provides a long period of myocardial protection. Despite widespread use in…

A meta-analysis of MitraClip system versus surgery for treatment of severe mitral regurgitation

Wan B, Rahnavardi M, Tian DH, Phan K, Munkholm-Larsen S, Bannon PG, Yan TD Ann Cardiothorac Surg 2013 Nov;2(6):683-92 PMID: 24349969 Abstract BACKGROUND: Mitral regurgitation (MR) is the second most common valvular heart disease after aortic stenosis. Without intervention, prognosis is poor in patients with severe symptomatic MR. While surgical repair is recommended for many…

The ARCH Projects: design and rationale (IAASSG 001)

Yan TD, Tian DH, LeMaire SA, Misfeld M, Elefteriades JA, Chen EP, Hughes GC, Kazui T, Griepp RB, Kouchoukos NT, Bannon PG, Underwood MJ, Mohr FW, Oo A, Sundt TM, Bavaria JE, Di Bartolomeo R, Di Eusanio M, Roselli EE, Beyersdorf F, Carrel TP, Corvera JS, Della Corte A, Ehrlich M, Hoffman A, Jakob H,…

Anaortic off-pump coronary artery bypass grafting in the elderly and very elderly

Cooper EA, Edelman JJ, Black D, Brereton RJ, Ross DE, Bannon PG, Wilson MK, Vallely MP Heart Lung Circ 2013 Dec;22(12):989-95 PMID: 23827207 Abstract BACKGROUND: Elderly patients undergoing surgical revascularisation may disproportionately benefit from avoiding manipulation of the ascending aorta and cardiopulmonary bypass. In this multi-centre observational study, we sought to determine the 30-day outcomes…

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