Research

Quantitative and temporal differences in coagulation, fibrinolysis and platelet activation after on-pump and off-pump coronary artery bypass surgery

Vallely MP, Bannon PG, Bayfield MS, Hughes CF, Kritharides L Heart Lung Circ 2009 Apr;18(2):123-30 PMID: 19081297 Abstract BACKGROUND: With the increasing use of OPCAB, potentially devastating thromboembolic events, including graft thrombosis may become increasingly evident. We present a study of the quantitative and temporal differences of the coagulation system, fibrinolysis and platelet activation after…

Covalent immobilisation of tropoelastin on a plasma deposited interface for enhancement of endothelialisation on metal surfaces

Yin Y, Wise SG, Nosworthy NJ, Waterhouse A, Bax DV, Youssef H, Byrom MJ, Bilek MM, McKenzie DR, Weiss AS, Ng MK Biomaterials 2009 Mar;30(9):1675-81 PMID: 19157535 Abstract Currently available endovascular metallic implants such as stents exhibit suboptimal biocompatibility in that they re-endothelialise poorly leaving them susceptible to thrombosis. To improve the interaction of these…

Management of the ascending aorta in patients with bicuspid aortic valve disease

Vallely MP, Semsarian C, Bannon PG Heart Lung Circ 2008 Oct;17(5):357-63 PMID: 18514024 Abstract Bicuspid aortic valve (BAV) disease is the most common form of congenital heart disease, affecting 1-2% of the population. Only 20% of patients will maintain normal valve function throughout their life and more than 30% of patients will develop serious morbidity….

Anaortic techniques reduce neurological morbidity after off-pump coronary artery bypass surgery

Vallely MP, Potger K, McMillan D, Hemli JM, Brady PW, Brereton RJ, Marshman D, Mathur MN, Ross DE Heart Lung Circ 2008 Aug;17(4):299-304 PMID: 18294911 Abstract BACKGROUND: Stroke remains one of the most devastating complications of cardiac surgery. Advocates of off-pump coronary revascularisation (OPCAB) maintain that post-operative neurologic morbidity is reduced by avoiding aortic cannulation…

Left ventricular support with the Impella LP 5.0 for cardiogenic shock following cardiac surgery

Rossiter-Thornton M, Arun V, Forrest AP, Bayfield MS, Wilson MK Heart Lung Circ 2008 Jun;17(3):243-5 PMID: 18436482 Abstract We report the first Australian use of the Impella LP 5.0, a minimally invasive, high-output left ventricular assist device. The device was inserted intra-operatively for cardiac failure following coronary artery grafting. Although it facilitated a temporary post-operative…

Accumulation of zinc in human atherosclerotic lesions correlates with calcium levels but does not protect against protein oxidation

Stadler N, Stanley N, Heeneman S, Vacata V, Daemen MJ, Bannon PG, Waltenberger J, Davies MJ Arterioscler. Thromb. Vasc. Biol. 2008 May;28(5):1024-30 PMID: 18309112 Abstract OBJECTIVE: Oxidized lipids and proteins, as well as decreased antioxidant levels, have been detected in human atherosclerotic lesions, with oxidation catalyzed by iron and copper postulated to contribute to lesion…

A kinetic model of bone marrow neutrophil production that characterizes late phenotypic maturation

Orr Y, Wilson DP, Taylor JM, Bannon PG, Geczy C, Davenport MP, Kritharides L Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007 Apr;292(4):R1707-16 PMID: 17185405 Abstract Acute inflammatory stimuli rapidly mobilize neutrophils from the bone marrow by shortening postmitotic maturation time and releasing younger neutrophils; however, the kinetics of this change in maturation time remains…

Apical ballooning syndrome complicated by acute severe mitral regurgitation with left ventricular outflow obstruction–case report

Chandrasegaram MD, Celermajer DS, Wilson MK J Cardiothorac Surg 2007;2:14 PMID: 17313686 Abstract BACKGROUND: Apical ballooning syndrome (or Takotsubo cardiomyopathy) is a syndrome of transient left ventricular apical ballooning. Although first described in Japanese patients, it is now well reported in the Caucasian population. The syndrome mimicks an acute myocardial infarction but is characterised by…

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